Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice

Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY(1-36) (SL-PYY(1-36)), are believed to improve glucose regulation in diabetes by targeting pancreatic islets. In this study, streptozotocin (STZ) diabetic transgenic Glu(CreERT2);ROSA26-eYFP and Ins1...

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Publicado en:Front Endocrinol (Lausanne)
Autores principales: Lafferty, Ryan A., Tanday, Neil, Moffett, R. Charlotte, Reimann, Frank, Gribble, Fiona M., Flatt, Peter R., Irwin, Nigel
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949013/
https://ncbi.nlm.nih.gov/pubmed/33716983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2021.633625
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