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Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation
Multinucleated giant cells are formed by the fusion of macrophages and are a characteristic feature in numerous pathophysiological conditions including the foreign body response (FBR). Foreign body giant cells (FBGCs) are inflammatory and destructive multinucleated macrophages and may cause damage a...
Gespeichert in:
| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7948992/ https://ncbi.nlm.nih.gov/pubmed/33262217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014597 |
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