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Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation

Multinucleated giant cells are formed by the fusion of macrophages and are a characteristic feature in numerous pathophysiological conditions including the foreign body response (FBR). Foreign body giant cells (FBGCs) are inflammatory and destructive multinucleated macrophages and may cause damage a...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Arya, Rakesh K., Goswami, Rishov, Rahaman, Shaik O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948992/
https://ncbi.nlm.nih.gov/pubmed/33262217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014597
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