Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

The transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2) regulates the expression of genes involved in antioxidant defenses to modulate fundamental cellular processes such as mitochondrial function and GSH metabolism. Previous reports proposed that mitochondrial reactive oxygen sp...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Cvetko, Filip, Caldwell, Stuart T., Higgins, Maureen, Suzuki, Takafumi, Yamamoto, Masayuki, Prag, Hiran A., Hartley, Richard C., Dinkova-Kostova, Albena T., Murphy, Michael P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948991/
https://ncbi.nlm.nih.gov/pubmed/33298526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016551
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