Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

The transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2) regulates the expression of genes involved in antioxidant defenses to modulate fundamental cellular processes such as mitochondrial function and GSH metabolism. Previous reports proposed that mitochondrial reactive oxygen sp...

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Vydáno v:J Biol Chem
Hlavní autoři: Cvetko, Filip, Caldwell, Stuart T., Higgins, Maureen, Suzuki, Takafumi, Yamamoto, Masayuki, Prag, Hiran A., Hartley, Richard C., Dinkova-Kostova, Albena T., Murphy, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948991/
https://ncbi.nlm.nih.gov/pubmed/33298526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016551
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