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Fc γ receptor compositional heterogeneity: Considerations for immunotherapy development

The antibody-binding crystallizable fragment (Fc) γ receptors (FcγRs) are expressed by leukocytes and activate or suppress a cellular response once engaged with an antibody-coated target. Therapeutic mAbs that require FcγR binding for therapeutic efficacy are now frontline treatments for multiple di...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Hovedforfatter: Barb, Adam W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948983/
https://ncbi.nlm.nih.gov/pubmed/33172893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.REV120.013168
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