Dissecting the low catalytic capability of flavin-dependent halogenases

Although flavin-dependent halogenases (FDHs) are attractive biocatalysts, their practical applications are limited because of their low catalytic efficiency. Here, we investigated the reaction mechanisms and structures of tryptophan 6-halogenase (Thal) from Streptomyces albogriseolus using stopped-f...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Phintha, Aisaraphon, Prakinee, Kridsadakorn, Jaruwat, Aritsara, Lawan, Narin, Visitsatthawong, Surawit, Kantiwiriyawanitch, Chadaporn, Songsungthong, Warangkhana, Trisrivirat, Duangthip, Chenprakhon, Pirom, Mulholland, Adrian, van Pée, Karl-Heinz, Chitnumsub, Penchit, Chaiyen, Pimchai
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948982/
https://ncbi.nlm.nih.gov/pubmed/33465708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016004
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