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Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress

The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high venous pressure– and fluid shear stress–induced vascular hyperpermeability in endothelial cells. However, the mechanism by which Piezo1 and TRPV4 channels execute the same function is poorly understood. Here we demon...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Swain, Sandip M., Liddle, Rodger A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948745/
https://ncbi.nlm.nih.gov/pubmed/33298523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015059
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