Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease

Eukaryotic initiation factor 2B (eIF2B) serves as a vital control point within protein synthesis and regulates translation initiation in response to cellular stress. Mutations within eIF2B result in the fatal disease, leukoencephalopathy with vanishing white matter (VWM). Previous biochemical studie...

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Gepubliceerd in:J Biol Chem
Hoofdauteurs: Norris, Karl, Hodgson, Rachel E., Dornelles, Tawni, Allen, K. Elizabeth, Abell, Ben M., Ashe, Mark P., Campbell, Susan G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948505/
https://ncbi.nlm.nih.gov/pubmed/33334879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014956
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