Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease

Eukaryotic initiation factor 2B (eIF2B) serves as a vital control point within protein synthesis and regulates translation initiation in response to cellular stress. Mutations within eIF2B result in the fatal disease, leukoencephalopathy with vanishing white matter (VWM). Previous biochemical studie...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Norris, Karl, Hodgson, Rachel E., Dornelles, Tawni, Allen, K. Elizabeth, Abell, Ben M., Ashe, Mark P., Campbell, Susan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948505/
https://ncbi.nlm.nih.gov/pubmed/33334879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014956
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