CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions

The initial activation step in the gating of ubiquitously expressed Orai1 calcium (Ca(2+)) ion channels represents the activation of the Ca(2+)-sensor protein STIM1 upon Ca(2+) store depletion of the endoplasmic reticulum. Previous studies using constitutively active Orai1 mutants gave rise to, but...

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Vydáno v:J Biol Chem
Hlavní autoři: Tiffner, Adéla, Schober, Romana, Höglinger, Carmen, Bonhenry, Daniel, Pandey, Saurabh, Lunz, Victoria, Sallinger, Matthias, Frischauf, Irene, Fahrner, Marc, Lindinger, Sonja, Maltan, Lena, Berlansky, Sascha, Stadlbauer, Michael, Schindl, Rainer, Ettrich, Rudiger, Romanin, Christoph, Derler, Isabella
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948504/
https://ncbi.nlm.nih.gov/pubmed/33361160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015548
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