Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition, and intersubunit electron transfer

Microbial metabolism of carnitine to trimethylamine (TMA) in the gut can accelerate atherosclerosis and heart disease, and these TMA-producing enzymes are therefore important drug targets. Here, we report the first structures of the carnitine oxygenase CntA, an enzyme of the Rieske oxygenase family....

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Quareshy, Mussa, Shanmugam, Muralidharan, Townsend, Eleanor, Jameson, Eleanor, Bugg, Timothy D.H., Cameron, Alexander D., Chen, Yin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948474/
https://ncbi.nlm.nih.gov/pubmed/33158989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016019
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