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Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition, and intersubunit electron transfer
Microbial metabolism of carnitine to trimethylamine (TMA) in the gut can accelerate atherosclerosis and heart disease, and these TMA-producing enzymes are therefore important drug targets. Here, we report the first structures of the carnitine oxygenase CntA, an enzyme of the Rieske oxygenase family....
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7948474/ https://ncbi.nlm.nih.gov/pubmed/33158989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016019 |
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