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Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo

Elongin A (EloA) is an essential transcription factor that stimulates the rate of RNA polymerase II (Pol II) transcription elongation in vitro. However, its role as a transcription factor in vivo has remained underexplored. Here we show that in mouse embryonic stem cells, EloA localizes to both thou...

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Vydáno v:J Biol Chem
Hlavní autoři: Ardehali, M. Behfar, Damle, Manashree, Perea-Resa, Carlos, Blower, Michael D., Kingston, Robert E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948453/
https://ncbi.nlm.nih.gov/pubmed/33334895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015877
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