SRSF3 and SRSF7 modulate 3′UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels

BACKGROUND: Alternative polyadenylation (APA) refers to the regulated selection of polyadenylation sites (PASs) in transcripts, which determines the length of their 3′ untranslated regions (3′UTRs). We have recently shown that SRSF3 and SRSF7, two closely related SR proteins, connect APA with mRNA e...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Schwich, Oliver Daniel, Blümel, Nicole, Keller, Mario, Wegener, Marius, Setty, Samarth Thonta, Brunstein, Melinda Elaine, Poser, Ina, Mozos, Igor Ruiz De Los, Suess, Beatrix, Münch, Christian, McNicoll, François, Zarnack, Kathi, Müller-McNicoll, Michaela
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948361/
https://ncbi.nlm.nih.gov/pubmed/33706811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02298-y
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