SRSF3 and SRSF7 modulate 3′UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels

BACKGROUND: Alternative polyadenylation (APA) refers to the regulated selection of polyadenylation sites (PASs) in transcripts, which determines the length of their 3′ untranslated regions (3′UTRs). We have recently shown that SRSF3 and SRSF7, two closely related SR proteins, connect APA with mRNA e...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genome Biol
Main Authors: Schwich, Oliver Daniel, Blümel, Nicole, Keller, Mario, Wegener, Marius, Setty, Samarth Thonta, Brunstein, Melinda Elaine, Poser, Ina, Mozos, Igor Ruiz De Los, Suess, Beatrix, Münch, Christian, McNicoll, François, Zarnack, Kathi, Müller-McNicoll, Michaela
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948361/
https://ncbi.nlm.nih.gov/pubmed/33706811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02298-y
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