SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly

SRSF7 is an essential RNA-binding protein whose misexpression promotes cancer. Here, we describe how SRSF7 maintains its protein homeostasis in murine P19 cells using an intricate negative feedback mechanism. SRSF7 binding to its premessenger RNA promotes inclusion of a poison cassette exon and tran...

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Publicat a:Nat Struct Mol Biol
Autors principals: Königs, Vanessa, de Oliveira Freitas Machado, Camila, Arnold, Benjamin, Blümel, Nicole, Solovyeva, Anfisa, Löbbert, Sinah, Schafranek, Michal, Ruiz De Los Mozos, Igor, Wittig, Ilka, McNicoll, Francois, Schulz, Marcel H., Müller-McNicoll, Michaela
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group US 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096898/
https://ncbi.nlm.nih.gov/pubmed/32123389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0385-9
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