SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly

SRSF7 is an essential RNA-binding protein whose misexpression promotes cancer. Here, we describe how SRSF7 maintains its protein homeostasis in murine P19 cells using an intricate negative feedback mechanism. SRSF7 binding to its premessenger RNA promotes inclusion of a poison cassette exon and tran...

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Publié dans:Nat Struct Mol Biol
Auteurs principaux: Königs, Vanessa, de Oliveira Freitas Machado, Camila, Arnold, Benjamin, Blümel, Nicole, Solovyeva, Anfisa, Löbbert, Sinah, Schafranek, Michal, Ruiz De Los Mozos, Igor, Wittig, Ilka, McNicoll, Francois, Schulz, Marcel H., Müller-McNicoll, Michaela
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group US 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096898/
https://ncbi.nlm.nih.gov/pubmed/32123389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0385-9
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