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SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly
SRSF7 is an essential RNA-binding protein whose misexpression promotes cancer. Here, we describe how SRSF7 maintains its protein homeostasis in murine P19 cells using an intricate negative feedback mechanism. SRSF7 binding to its premessenger RNA promotes inclusion of a poison cassette exon and tran...
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| Опубликовано в: : | Nat Struct Mol Biol |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group US
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7096898/ https://ncbi.nlm.nih.gov/pubmed/32123389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0385-9 |
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