SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly

SRSF7 is an essential RNA-binding protein whose misexpression promotes cancer. Here, we describe how SRSF7 maintains its protein homeostasis in murine P19 cells using an intricate negative feedback mechanism. SRSF7 binding to its premessenger RNA promotes inclusion of a poison cassette exon and tran...

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Pubblicato in:Nat Struct Mol Biol
Autori principali: Königs, Vanessa, de Oliveira Freitas Machado, Camila, Arnold, Benjamin, Blümel, Nicole, Solovyeva, Anfisa, Löbbert, Sinah, Schafranek, Michal, Ruiz De Los Mozos, Igor, Wittig, Ilka, McNicoll, Francois, Schulz, Marcel H., Müller-McNicoll, Michaela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group US 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096898/
https://ncbi.nlm.nih.gov/pubmed/32123389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0385-9
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