Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer

OBJECTIVE: ATM serine/threonine kinase (ATM) is the most frequently mutated DNA damage response gene, involved in homologous recombination (HR), in pancreatic ductal adenocarcinoma (PDAC). DESIGN: Combinational synergy screening was performed to endeavour a genotype-tailored targeted therapy. RESULT...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Gout, Johann, Perkhofer, Lukas, Morawe, Mareen, Arnold, Frank, Ihle, Michaela, Biber, Stephanie, Lange, Sebastian, Roger, Elodie, Kraus, Johann M, Stifter, Katja, Hahn, Stephan A, Zamperone, Andrea, Engleitner, Thomas, Müller, Martin, Walter, Karolin, Rodriguez-Aznar, Eva, Sainz Jr, Bruno, Hermann, Patrick C, Hessmann, Elisabeth, Müller, Sebastian, Azoitei, Ninel, Lechel, André, Liebau, Stefan, Wagner, Martin, Simeone, Diane M, Kestler, Hans A, Seufferlein, Thomas, Wiesmüller, Lisa, Rad, Roland, Frappart, Pierre-Olivier, Kleger, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Pancreas
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948173/
https://ncbi.nlm.nih.gov/pubmed/32873698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2019-319970
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