Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer

OBJECTIVE: ATM serine/threonine kinase (ATM) is the most frequently mutated DNA damage response gene, involved in homologous recombination (HR), in pancreatic ductal adenocarcinoma (PDAC). DESIGN: Combinational synergy screening was performed to endeavour a genotype-tailored targeted therapy. RESULT...

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Vydáno v:Gut
Hlavní autoři: Gout, Johann, Perkhofer, Lukas, Morawe, Mareen, Arnold, Frank, Ihle, Michaela, Biber, Stephanie, Lange, Sebastian, Roger, Elodie, Kraus, Johann M, Stifter, Katja, Hahn, Stephan A, Zamperone, Andrea, Engleitner, Thomas, Müller, Martin, Walter, Karolin, Rodriguez-Aznar, Eva, Sainz Jr, Bruno, Hermann, Patrick C, Hessmann, Elisabeth, Müller, Sebastian, Azoitei, Ninel, Lechel, André, Liebau, Stefan, Wagner, Martin, Simeone, Diane M, Kestler, Hans A, Seufferlein, Thomas, Wiesmüller, Lisa, Rad, Roland, Frappart, Pierre-Olivier, Kleger, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2021
Témata:
Pancreas
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948173/
https://ncbi.nlm.nih.gov/pubmed/32873698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2019-319970
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