Suboptimal Global Transcriptional Response Increases the Harmful Effects of Loss-of-Function Mutations

The fitness impact of loss-of-function mutations is generally assumed to reflect the loss of specific molecular functions associated with the perturbed gene. Here, we propose that rewiring of the transcriptome upon deleterious gene inactivation is frequently nonspecific and mimics stereotypic respon...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Kovács, Károly, Farkas, Zoltán, Bajić, Djordje, Kalapis, Dorottya, Daraba, Andreea, Almási, Karola, Kintses, Bálint, Bódi, Zoltán, Notebaart, Richard A, Poyatos, Juan F, Kemmeren, Patrick, Holstege, Frank C P, Pál, Csaba, Papp, Balázs
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Discoveries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7947755/
https://ncbi.nlm.nih.gov/pubmed/33306797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msaa280
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