Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover

Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was engineered to translate a codon ambiguously (mistra...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Kalapis, Dorottya, Bezerra, Ana R., Farkas, Zoltán, Horvath, Peter, Bódi, Zoltán, Daraba, Andreea, Szamecz, Béla, Gut, Ivo, Bayes, Mónica, Santos, Manuel A. S., Pál, Csaba
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636289/
https://ncbi.nlm.nih.gov/pubmed/26544557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002291
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