Porcine model elucidates function of p53 isoform in carcinogenesis and reveals novel circTP53 RNA

Recent years have seen an increasing number of genetically engineered pig models of human diseases including cancer. We previously generated pigs with a modified TP53 allele that carries a Cre-removable transcriptional stop signal in intron 1, and an oncogenic mutation TP53(R167H) (orthologous to hu...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncogene
Prif Awduron: Niu, Guanglin, Hellmuth, Isabel, Flisikowska, Tatiana, Pausch, Hubert, Rieblinger, Beate, Carrapeiro, Alexander, Schade, Benjamin, Böhm, Brigitte, Kappe, Eva, Fischer, Konrad, Klinger, Bernhard, Steiger, Katja, Burgkart, Reiner, Bourdon, Jean-Christophe, Saur, Dieter, Kind, Alexander, Schnieke, Angelika, Flisikowski, Krzysztof
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946636/
https://ncbi.nlm.nih.gov/pubmed/33603167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01686-9
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