Porcine model elucidates function of p53 isoform in carcinogenesis and reveals novel circTP53 RNA

Recent years have seen an increasing number of genetically engineered pig models of human diseases including cancer. We previously generated pigs with a modified TP53 allele that carries a Cre-removable transcriptional stop signal in intron 1, and an oncogenic mutation TP53(R167H) (orthologous to hu...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Niu, Guanglin, Hellmuth, Isabel, Flisikowska, Tatiana, Pausch, Hubert, Rieblinger, Beate, Carrapeiro, Alexander, Schade, Benjamin, Böhm, Brigitte, Kappe, Eva, Fischer, Konrad, Klinger, Bernhard, Steiger, Katja, Burgkart, Reiner, Bourdon, Jean-Christophe, Saur, Dieter, Kind, Alexander, Schnieke, Angelika, Flisikowski, Krzysztof
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946636/
https://ncbi.nlm.nih.gov/pubmed/33603167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01686-9
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