A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation

In addition to their well characterized role in mediating IgE-dependent allergic diseases, aberrant accumulation and activation of mast cells (MCs) is associated with many non-allergic inflammatory diseases, whereby their activation is likely triggered by non-IgE stimuli (e.g., IL-33). Siglec-8 is a...

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Détails bibliographiques
Publié dans:Mucosal Immunol
Auteurs principaux: Schanin, Julia, Gebremeskel, Simon, Korver, Wouter, Falahati, Rustom, Butuci, Melina, Haw, Tatt Jhong, Nair, Prema M., Liu, Gang, Hansbro, Nicole G., Hansbro, Philip M., Evensen, Erik, Brock, Emily C., Xu, Alan, Wong, Alan, Leung, John, Bebbington, Christopher, Tomasevic, Nenad, Youngblood, Bradford A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group US 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946634/
https://ncbi.nlm.nih.gov/pubmed/32814824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-020-00336-9
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