HIF-1 Inhibitor YC-1 Reverses the Acquired Resistance of EGFR-Mutant HCC827 Cell Line with MET Amplification to Gefitinib

BACKGROUND: Acquired resistance occurred in the majority of nonsmall cell lung cancer (NSCLC) patients receiving epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) therapy, and this may be related to the activation of the HIF-1 pathway. Therefore, we examined the influence of th...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Jin, Qian, Zheng, Jisheng, Chen, Ming, Jiang, Na, Xu, Xianrong, Huang, Feihua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946473/
https://ncbi.nlm.nih.gov/pubmed/33763171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6633867
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