Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation

Ataxin-2 (Atx2) is a translational control molecule mutated in spinocerebellar ataxia type II and amyotrophic lateral sclerosis. While intrinsically disordered domains (IDRs) of Atx2 facilitate mRNP condensation into granules, how IDRs work with structured domains to enable positive and negative reg...

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Vydáno v:eLife
Hlavní autoři: Singh, Amanjot, Hulsmeier, Joern, Kandi, Arvind Reddy, Pothapragada, Sai Shruti, Hillebrand, Jens, Petrauskas, Arnas, Agrawal, Khushboo, RT, Krishnan, Thiagarajan, Devasena, Jayaprakashappa, Deepa, VijayRaghavan, K, Ramaswami, Mani, Bakthavachalu, Baskar
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2021
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946432/
https://ncbi.nlm.nih.gov/pubmed/33689682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60326
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