Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation

Ataxin-2 (Atx2) is a translational control molecule mutated in spinocerebellar ataxia type II and amyotrophic lateral sclerosis. While intrinsically disordered domains (IDRs) of Atx2 facilitate mRNP condensation into granules, how IDRs work with structured domains to enable positive and negative reg...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Singh, Amanjot, Hulsmeier, Joern, Kandi, Arvind Reddy, Pothapragada, Sai Shruti, Hillebrand, Jens, Petrauskas, Arnas, Agrawal, Khushboo, RT, Krishnan, Thiagarajan, Devasena, Jayaprakashappa, Deepa, VijayRaghavan, K, Ramaswami, Mani, Bakthavachalu, Baskar
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946432/
https://ncbi.nlm.nih.gov/pubmed/33689682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60326
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados