Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia

How metabolic status controls the fates of different types of leukemia cells remains elusive. Using a SoNar-transgenic mouse line, we demonstrated that B cell acute lymphoblastic leukemia (B-ALL) cells had a preference in using oxidative phosphorylation. B-ALL cells with a low SoNar ratio (SoNar-low...

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Udgivet i:Sci Adv
Main Authors: Chen, Chiqi, Hao, Xiaoxin, Lai, Xiaoyun, Liu, Ligen, Zhu, Jun, Shao, Hongfang, Huang, Dan, Gu, Hao, Zhang, Tinghua, Yu, Zhuo, Xie, Li, Zhang, Xiaocui, Yang, Yi, Xu, Jun, Zhao, Yuzheng, Lu, Zhigang, Zheng, Junke
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2021
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946372/
https://ncbi.nlm.nih.gov/pubmed/33692103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd6280
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