Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103(+) and Gut CD4(+) T Cells

Latent HIV infection is the main barrier to cure, and most HIV-infected cells reside in the gut, where distinct but unknown mechanisms may promote viral latency. Transforming growth factor β (TGF-β), which induces the expression of CD103 on tissue-resident memory T cells, has been implicated in HIV...

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Veröffentlicht in:J Virol
Hauptverfasser: Yukl, Steven A., Khan, Shahzada, Chen, Tsui-Hua, Trapecar, Martin, Wu, Frank, Xie, Guorui, Telwatte, Sushama, Fulop, Daniel, Pico, Alexander R., Laird, Gregory M., Ritter, Kristen D., Jones, Norman G., Lu, Chuanyi M., Siliciano, Robert F., Roan, Nadia R., Milush, Jeffrey M., Somsouk, Ma, Deeks, Steven G., Hunt, Peter W., Sanjabi, Shomyseh
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7944458/
https://ncbi.nlm.nih.gov/pubmed/33115867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01331-20
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