Viral Subpopulation Screening Guides in Designing a High Interferon-Inducing Live Attenuated Influenza Vaccine by Targeting Rare Mutations in NS1 and PB2 Proteins

Influenza A viruses continue to circulate among wild birds and poultry worldwide, posing constant pandemic threats to humans. Effective control of emerging influenza viruses requires new broadly protective vaccines. Live attenuated influenza vaccines with truncations in nonstructural protein 1 (NS1)...

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Vydáno v:J Virol
Hlavní autoři: Ghorbani, Amir, Abundo, Michael C., Ji, Hana, Taylor, Kara J. M., Ngunjiri, John M., Lee, Chang-Won
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7944443/
https://ncbi.nlm.nih.gov/pubmed/33115873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01722-20
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