Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

Small cell lung cancer (SCLC) is classified as a high-grade neuroendocrine (NE) tumor, but a subset of SCLC has been termed “variant” due to the loss of NE characteristics. In this study, we computed NE scores for patient-derived SCLC cell lines and xenografts, as well as human tumors. We aligned NE...

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Veröffentlicht in:Commun Biol
Hauptverfasser: Cai, Ling, Liu, Hongyu, Huang, Fang, Fujimoto, Junya, Girard, Luc, Chen, Jun, Li, Yongwen, Zhang, Yu-An, Deb, Dhruba, Stastny, Victor, Pozo, Karine, Kuo, Christin S., Jia, Gaoxiang, Yang, Chendong, Zou, Wei, Alomar, Adeeb, Huffman, Kenneth, Papari-Zareei, Mahboubeh, Yang, Lin, Drapkin, Benjamin, Akbay, Esra A., Shames, David S., Wistuba, Ignacio I., Wang, Tao, Johnson, Jane E., Xiao, Guanghua, DeBerardinis, Ralph J., Minna, John D., Xie, Yang, Gazdar, Adi F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943563/
https://ncbi.nlm.nih.gov/pubmed/33750914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01842-7
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