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Multi-scale dynamical modelling of T-cell development from an early thymic progenitor state to lineage commitment

Intrathymic development of committed pro-T-cells from multipotent hematopoietic precursors offers a unique opportunity to dissect the molecular circuitry establishing cell identity in response to environmental signals. This transition encompasses programmed shutoff of stem/progenitor genes, upregula...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Olariu, Victor, Yui, Mary A., Krupinski, Pawel, Zhou, Wen, Deichmann, Julia, Andersson, Emil, Rothenberg, Ellen V., Peterson, Carsten
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943435/
https://ncbi.nlm.nih.gov/pubmed/33440162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108622
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