Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2

Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-converting enzyme II (ACE2). Here, we deliberately exploit non-neutralizing RBD antibodies, showing they can dramatically assist...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Lim, Shion A., Gramespacher, Josef A., Pance, Katarina, Rettko, Nicholas J., Solomon, Paige, Jin, Jing, Lui, Irene, Elledge, Susanna K., Liu, Jia, Bracken, Colton J., Simmons, Graham, Zhou, Xin X., Leung, Kevin K., Wells, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939556/
https://ncbi.nlm.nih.gov/pubmed/33666135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2021.1893426
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