Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2

Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-converting enzyme II (ACE2). Here, we deliberately exploit non-neutralizing RBD antibodies, showing they can dramatically assist...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Lim, Shion A., Gramespacher, Josef A., Pance, Katarina, Rettko, Nicholas J., Solomon, Paige, Jin, Jing, Lui, Irene, Elledge, Susanna K., Liu, Jia, Bracken, Colton J., Simmons, Graham, Zhou, Xin X., Leung, Kevin K., Wells, James A.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2021
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939556/
https://ncbi.nlm.nih.gov/pubmed/33666135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2021.1893426
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