Stress-induced nuclear condensation of NELF drives transcriptional downregulation

In response to stress, human cells coordinately downregulate transcription and translation of housekeeping genes. To downregulate transcription, the negative elongation factor (NELF) is recruited to gene promoters impairing RNA polymerase II elongation. Here we report that NELF rapidly forms nuclear...

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Pubblicato in:Mol Cell
Autori principali: Rawat, Prashant, Boehning, Marc, Hummel, Barbara, Aprile-Garcia, Fernando, Pandit, Anwit S., Eisenhardt, Nathalie, Khavaran, Ashkan, Niskanen, Einari, Vos, Seychelle M., Palvimo, Jorma J., Pichler, Andrea, Cramer, Patrick, Sawarkar, Ritwick
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939545/
https://ncbi.nlm.nih.gov/pubmed/33548202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.01.016
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