Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets

Androgen receptor (AR) is a male sex steroid-activated transcription factor (TF) that plays a critical role in prostate cancers, including castration-resistant prostate cancers (CRPC) that typically express amplified levels of the AR. CRPC-derived VCaP cells display an excessive number of chromatin...

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Pubblicato in:Sci Rep
Autori principali: Toropainen, Sari, Niskanen, Einari A., Malinen, Marjo, Sutinen, Päivi, Kaikkonen, Minna U., Palvimo, Jorma J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027586/
https://ncbi.nlm.nih.gov/pubmed/27641228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33510
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