α-Synuclein facilitates endocytosis by elevating the steady-state levels of phosphatidylinositol 4,5-bisphosphate

α-Synuclein (α-Syn) is a protein implicated in the pathogenesis of Parkinson's disease (PD). It is an intrinsically disordered protein that binds acidic phospholipids. Growing evidence supports a role for α-Syn in membrane trafficking, including, mechanisms of endocytosis and exocytosis, althou...

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Vydáno v:J Biol Chem
Hlavní autoři: Schechter, Meir, Atias, Merav, Abd Elhadi, Suaad, Davidi, Dana, Gitler, Daniel, Sharon, Ronit
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939461/
https://ncbi.nlm.nih.gov/pubmed/33087443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015319
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