Murine GFP-Mx1 forms nuclear condensates and associates with cytoplasmic intermediate filaments: Novel antiviral activity against VSV

Type I and III interferons induce expression of the “myxovirus resistance proteins” MxA in human cells and its ortholog Mx1 in murine cells. Human MxA forms cytoplasmic structures, whereas murine Mx1 forms nuclear bodies. Whereas both HuMxA and MuMx1 are antiviral toward influenza A virus (FLUAV) (a...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Sehgal, Pravin B., Yuan, Huijuan, Scott, Mia F., Deng, Yan, Liang, Feng-Xia, Mackiewicz, Andrzej
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939456/
https://ncbi.nlm.nih.gov/pubmed/33077519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015661
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