Tuning the Antigen Density Requirement for CAR T Cell Activity

Insufficient reactivity against cells with low antigen density has emerged as an important cause of CAR resistance. Little is known about factors that modulate the threshold for antigen recognition. We demonstrate that CD19 CAR activity is dependent upon antigen density and the CAR construct in axic...

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Publicado no:Cancer Discov
Main Authors: Majzner, Robbie G., Rietberg, Skyler P., Sotillo, Elena, Dong, Rui, Vachharajani, Vipul T., Labanieh, Louai, Myklebust, June H., Kadapakkam, Meena, Weber, Evan W., Tousley, Aidan M., Richards, Rebecca M., Heitzeneder, Sabine, Nguyen, Sang M., Wiebking, Volker, Theruvath, Johanna, Lynn, Rachel C., Xu, Peng, Dunn, Alexander R., Vale, Ronald D., Mackall, Crystal L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939454/
https://ncbi.nlm.nih.gov/pubmed/32193224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0945
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