Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1–JNK axis

Postoperative recurrence from microscopic residual disease must be prevented to cure intractable cancers, including pancreatic cancer. Key to this goal is the elimination of cancer stem cells (CSCs) endowed with tumor-initiating capacity and drug resistance. However, current therapeutic strategies c...

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Vydáno v:J Biol Chem
Hlavní autoři: Suzuki, Shuhei, Okada, Masashi, Sanomachi, Tomomi, Togashi, Keita, Seino, Shizuka, Sato, Atsushi, Yamamoto, Masahiro, Kitanaka, Chifumi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939393/
https://ncbi.nlm.nih.gov/pubmed/33115754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015223
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