A New Mouse Model Related to SCA14 Carrying a Pseudosubstrate Domain Mutation in PKCγ Shows Perturbed Purkinje Cell Maturation and Ataxic Motor Behavior

Spinocerebellar ataxias (SCAs) are diseases characterized by cerebellar atrophy and loss of Purkinje neurons caused by mutations in diverse genes. In SCA14, the disease is caused by point mutations or small deletions in protein kinase C γ (PKCγ), a crucial signaling protein in Purkinje cells. It is...

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Vydáno v:J Neurosci
Hlavní autoři: Shimobayashi, Etsuko, Kapfhammer, Josef P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939089/
https://ncbi.nlm.nih.gov/pubmed/33478986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1946-20.2021
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