Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation

Spinocerebellar ataxia type 14 (SCA14) is a subtype of the autosomal dominant cerebellar ataxias that is characterized by slowly progressive cerebellar dysfunction and neurodegeneration. SCA14 is caused by mutations in the PRKCG gene, encoding protein kinase C gamma (PKCγ). Despite the identificatio...

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Bibliografische gegevens
Gepubliceerd in:Acta Neuropathol Commun
Hoofdauteurs: Wong, Maggie M. K., Hoekstra, Stephanie D., Vowles, Jane, Watson, Lauren M., Fuller, Geraint, Németh, Andrea H., Cowley, Sally A., Ansorge, Olaf, Talbot, Kevin, Becker, Esther B. E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151931/
https://ncbi.nlm.nih.gov/pubmed/30249303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0600-7
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