Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM

IgG antibodies play a role in malaria immunity, but whether and how IgM protects from malaria and the biology of Plasmodium falciparum (Pf)–specific IgM B cells is unclear. In a Mali cohort spanning infants to adults, we conducted longitudinal analyses of Pf- and influenza-specific B cells. We found...

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Publié dans:J Exp Med
Auteurs principaux: Hopp, Christine S., Sekar, Padmapriya, Diouf, Ababacar, Miura, Kazutoyo, Boswell, Kristin, Skinner, Jeff, Tipton, Christopher M., Peterson, Mary E., Chambers, Michael J., Andrews, Sarah, Lu, Jinghua, Tan, Joshua, Li, Shanping, Doumbo, Safiatou, Kayentao, Kassoum, Ongoiba, Aissata, Traore, Boubacar, Portugal, Silvia, Sun, Peter D., Long, Carole, Koup, Richard A., Long, Eric O., McDermott, Adrian B., Crompton, Peter D.
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7938365/
https://ncbi.nlm.nih.gov/pubmed/33661303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200901
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