Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM

IgG antibodies play a role in malaria immunity, but whether and how IgM protects from malaria and the biology of Plasmodium falciparum (Pf)–specific IgM B cells is unclear. In a Mali cohort spanning infants to adults, we conducted longitudinal analyses of Pf- and influenza-specific B cells. We found...

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Publicado no:J Exp Med
Main Authors: Hopp, Christine S., Sekar, Padmapriya, Diouf, Ababacar, Miura, Kazutoyo, Boswell, Kristin, Skinner, Jeff, Tipton, Christopher M., Peterson, Mary E., Chambers, Michael J., Andrews, Sarah, Lu, Jinghua, Tan, Joshua, Li, Shanping, Doumbo, Safiatou, Kayentao, Kassoum, Ongoiba, Aissata, Traore, Boubacar, Portugal, Silvia, Sun, Peter D., Long, Carole, Koup, Richard A., Long, Eric O., McDermott, Adrian B., Crompton, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7938365/
https://ncbi.nlm.nih.gov/pubmed/33661303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200901
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