Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers

The kynurenine pathway (KP) is the main path for tryptophan metabolism, and it represents a multitude of potential sites for drug discovery in neuroscience, including pain, stroke, and epilepsy. L‐kynurenine (LKYN), the first active metabolite in the pathway, emerges to be a prodrug targeting glutam...

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Bibliographische Detailangaben
Veröffentlicht in:Pharmacol Res Perspect
Hauptverfasser: Al‐Karagholi, Mohammad Al‐Mahdi, Hansen, Jakob Møller, Abou‐Kassem, Dalia, Hansted, Anna Koldbro, Ubhayasekera, Kumari, Bergquist, Jonas, Vécsei, László, Jansen‐Olesen, Inger, Ashina, Messoud
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7937944/
https://ncbi.nlm.nih.gov/pubmed/33682377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.741
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