The Effect of K(ATP) Channel Blocker Glibenclamide on CGRP-Induced Headache and Hemodynamic in Healthy Volunteers

BACKGROUND: Calcitonin gene-related peptide (CGRP) dilates cranial arteries and triggers headache. The CGRP signaling pathway is partly dependent on activation of ATP-sensitive potassium (K(ATP)) channels. Here, we investigated the effect of the K(ATP) channel blocker glibenclamide on CGRP-induced h...

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Pubblicato in:Front Physiol
Autori principali: Coskun, Hande, Elbahi, Fatima Azzahra, Al-Karagholi, Mohammad Al-Mahdi, Ghanizada, Hashmat, Sheykhzade, Majid, Ashina, Messoud
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8226177/
https://ncbi.nlm.nih.gov/pubmed/34177610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.652136
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