Lumacaftor/ivacaftor therapy fails to increase insulin secretion in F508del/F508del CF patients

BACKGROUND: Glucose tolerance abnormalities including cystic fibrosis related diabetes (CFRD) are common in patients with cystic fibrosis (CF). The underlying pathophysiology is not fully understood. Emerging evidence suggests that CFTR dysfunction may directly or indirectly impact β-cell function,...

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Publicado en:J Cyst Fibros
Autores principales: Moheet, Amir, Beisang, Daniel, Zhang, Lin, Sagel, Scott D., VanDalfsen, Jill M., Heltshe, Sonya L., Frederick, Carla, Mann, Michelle, Antos, Nicholas, Billings, Joanne, Rowe, Steven M., Moran, Antoinette
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7937760/
https://ncbi.nlm.nih.gov/pubmed/32917547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcf.2020.09.001
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