Lumacaftor/ivacaftor therapy fails to increase insulin secretion in F508del/F508del CF patients

BACKGROUND: Glucose tolerance abnormalities including cystic fibrosis related diabetes (CFRD) are common in patients with cystic fibrosis (CF). The underlying pathophysiology is not fully understood. Emerging evidence suggests that CFTR dysfunction may directly or indirectly impact β-cell function,...

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Vydáno v:J Cyst Fibros
Hlavní autoři: Moheet, Amir, Beisang, Daniel, Zhang, Lin, Sagel, Scott D., VanDalfsen, Jill M., Heltshe, Sonya L., Frederick, Carla, Mann, Michelle, Antos, Nicholas, Billings, Joanne, Rowe, Steven M., Moran, Antoinette
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7937760/
https://ncbi.nlm.nih.gov/pubmed/32917547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcf.2020.09.001
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