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Nuclear envelope wrinkling predicts mesenchymal progenitor cell mechano-response in 2D and 3D microenvironments

Exogenous mechanical cues are transmitted from the extracellular matrix to the nuclear envelope (NE), where mechanical stress on the NE mediates shuttling of transcription factors and other signaling cascades that dictate downstream cellular behavior and fate decisions. To systematically study how n...

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Detalles Bibliográficos
Publicado en:Biomaterials
Main Authors: Cosgrove, Brian D., Loebel, Claudia, Driscoll, Tristan P., Tsinman, Tonia K., Dai, Eric N., Heo, Su-Jin, Dyment, Nathaniel A., Burdick, Jason A., Mauck, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936657/
https://ncbi.nlm.nih.gov/pubmed/33540172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2021.120662
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